During the Second World War he was a chief surgeon under Generals Patton and Simpson during the invasion of Europe.
In 1948 he and Georgeanna became part-time faculty in the department of gynecology and obstetrics in the school of medicine at Johns Hopkins. In 1960 they left their private practice to become full-time faculty.
Their 1965 textbook with Edmund Novak went through several editions and in its time outsold all other such textbooks combined.
Howard did the ‘corrective’ surgery on John Money’s intersex infants, and in 1965 when Money started the Gender Identity Clinic at Johns Hopkins Hospital, he did the surgery on their transsexual patients starting with Phyllis Avon Wilson. The infant David Reimer was reassigned to female in 1967. Dawn Langley Hall had surgery in 1968, and maybe Kiira Treia in 1974. Howard also established the crytogenetics laboratory at Johns Hopkins when the field was in its infancy.
The Joneses retired from Johns Hopkins in 1978, actually just before the Gender Identity Clinic was closed, and were then appointed professors of obstetrics and gynecology at Eastern Virginia Medical School, where they established the first in vitro fertilization program in the United States.
The Jones were the only gynecologists from the US invited to advise the Catholic Pope on assisted reproduction.
- Edmund R. Novak, Georgeanna Seegar Jones, and Howard Wilbur Jones. Textbook of Gynecology Baltimore: Williams & Wilkins Co, 1965.
- Howard Wilbur Jones, and William Wallace Scott. Hermaphroditism, Genital Anomalies and Related Endocrine Disorders. Baltimore: Williams & Wilkins Co, 1971.
- Howard Wilbur Jones, and Charlotte Schrader. In Vitro Fertilization and Other Assisted Reproduction. Annals of the New York Academy of Sciences, v. 541. New York, N.Y.: New York Academy of Sciences, 1988.
- “The Howard W. Jones, Jr. Collection”. Medical Archives. 1999. www.medicalarchives.jhmi.edu/sgml/joneshw.html.
- Howard Wilbur Jones, and Georgeanna Seegar Jones. War and Love: A Surgeon's Memoir of Battlefield Medicine During World War II with Letters to and from Home. Philadelphia: Xlibris, 2004.
As Harold Benjamin became a sex-change doctor after the normal age of retirement, so the Jones started their career in in vitro fertilization also after retirement age.